Research About Hydroxychloroquine Make You Sleepy

Hydroxychloroquine, often abbreviated as HCQ, is a medication derived from chloroquine, originally designed for the treatment and prevention of malaria. Over time, HCQ has found a niche in addressing various autoimmune conditions, such as rheumatoid arthritis and lupus, owing to its immunomodulatory properties. It is categorized as both an antimalarial and antirheumatic drug. Here we will briefly discuss why hydroxychloroquine make you sleepy.

The mechanisms by which HCQ achieves its therapeutic effects are multifaceted and intricate. One of its primary actions involves the inhibition of specific enzymes implicated in the immune response. Consequently, it suppresses excessive immune system activity, a common feature of autoimmune diseases. Additionally, HCQ is believed to interfere with lysosomal function, organelles responsible for breaking down cellular waste materials and components, which can impact cellular function and signalling in various ways.

Connection Between HCQ and Drowsiness 

Drowsiness is characterized by excessive daytime sleepiness. Hydroxychloroquine make you sleepy is not typically listed as a direct side effect. Nonetheless, it’s crucial to acknowledge that individual responses to medications can vary, and at times, unexpected side effects may manifest. If individuals taking HCQ report drowsiness, several factors might contribute to this phenomenon:

Medical Conditions:

     Many individuals prescribed HCQ already grappling with autoimmune disorders like rheumatoid arthritis or lupus. These conditions can independently lead to fatigue, sleep disturbances, and drowsiness, unrelated to the medication itself.

    Other Medications:

     HCQ can interact with other medications that patients might be taking concurrently. Should any of these medications list drowsiness as a side effect, the combined influence with hydroxychloroquine make you sleepy.

    Individual Reports:

    Responses to medications vary from person to person. Some individuals may report drowsiness as a side effect, even if it is not a common occurrence.

    Time of Dosage:

    Both the HCQ dosage and the timing of administration can influence the likelihood of experiencing drowsiness. Higher doses might result in more pronounced side effects, and the timing of HCQ intake may affect sleep patterns.

    Psychological Elements: 

    Sleep disturbance and feelings of tiredness may be caused by anxiety or stress due to taking a new drug or worrying about potential adverse effects.

    Scientific Research on Hydroxychloroquine make you sleepy

    While there is limited research specifically dedicated to investigating the sedative effects of hydroxychloroquine, some studies and anecdotal reports have touched upon this topic about hydroxychloroquine make you sleepy. It’s vital to note that these findings are not conclusive, and further research is warranted to establish a definitive link between HCQ and drowsiness.

    Comprehensive Studies:

    There is a dearth of comprehensive studies investigating the side effects of HCQ, with drowsiness not consistently emerging as a prominent concern. The majority of clinical trials and research studies on HCQ predominantly focus on its effectiveness and safety profile in managing specific medical conditions, rather than its potential sedative effects.

      Reports on Cases:

      Some case reports document instances of patients experiencing that hydroxychloroquine make you sleepy. Nevertheless, case reports are typically regarded as anecdotal evidence and may not accurately represent the broader population.

      Individual Variability:

      The variation in how each person reacts to drugs continues to be crucial. While many people may not experience this symptom, other people may list drowsiness as a side effect.

      hydroxychloroquine make you sleepy

      The Role of Lysosomes in Cellular Function

      To grasp the potential mechanisms behind hydroxychloroquine make you sleepy, it is necessary to delve into one of the known cellular effects of the drug: its impact on lysosomes.

      Cellular organelles called lysosomes are responsible for dissolving a wide range of substances, including waste and cellular debris. Enzymes are crucial for breaking down and recycling cellular components within these organelles.

      HCQ is believed to accumulate within lysosomes, altering their pH levels (making them less acidic) and impairing their functionality. This disruption of lysosomal function can have far-reaching consequences on cellular processes. It can affect the autophagy process, essential for cellular self-maintenance and cleanliness. On some occasions, lysosomal dysfunction has been linked to cellular stress responses and altered signalling pathways, potentially influencing overall cellular energy and function.

      It is crucial to stress that although lysosomal dysfunction may be a cellular side effect of this medication, the connection between this cellular effect and lethargy in people has not yet been conclusively proven.

      Managing Drowsiness While Taking Hydroxychloroquine

      Should you be prescribed HCQ and experience that hydroxychloroquine make you sleepy as a side effect, it is vital to address this concern with your healthcare provider. They can provide tailored guidance on managing this symptom effectively.

      Here are some general tips:


      Discuss your medication-taking schedule with your doctor. To lessen the possibility of hydroxychloroquine affecting your sleep habits, they could advise taking medication at a different time of day.

        Medication Review:

        To ensure your safety and well-being, your doctor may conduct a thorough evaluation of your medication regimen, specifically looking for any potential drug interactions that could lead to drowsiness.

        Adjusting Dosage:

        In some cases, it may be possible to maintain the beneficial effects of the medication while minimizing unwanted side effects by making changes to the dosage.

        Lifestyle Adjustments:

        In addition to medication management, addressing drowsiness may require making lifestyle modifications. These can include improving sleep habits, reducing stress levels, and incorporating regular physical activity into your routine.

        Strategies to Reduce Sleepiness from Hydroxychloroquine

        Timing Matters:

        Consider taking your dose at night, just before bedtime because hydroxychloroquine make you sleepy. This approach can help mitigate the side effects of the medication during your waking hours, allowing you to rest when drowsiness is more acceptable.

        Take with Food:

        Avoid taking it on an empty stomach. Instead, have it with a meal or snack. This can help reduce the likelihood of nausea and other related side effects.

        Stay Hydrated:

        Keep yourself adequately hydrated throughout the day. Dizziness and weariness, two possible side effects of the medicine, can be reduced with proper drinking.

        Include a Regular Exercise Program:

        Consistent exercise can enhance the quality of your sleep overall. However, exercise shouldn’t be done too soon before night because it could have a stimulating effect.

        Organize Your Sleep Schedule:

        Establish a consistent sleep routine and follow it as closely as you can, including on the weekends. Consistency can aid in regulating your body’s biological clock and lessen sleep disruptions.

        Relaxing Bedtime Routine:

        Regular routine of going to bed will signal your body on a daily basis to sleep at that exact time. Activities like taking a warm bath, reading a book, or listening to calming music can promote relaxation where hydroxychloroquine make you sleepy.

        Avoid Stimulants:

        Avoid consuming caffeine and alcohol in the hours leading up to bedtime. Because these types of consumptions can damage your ability to fall asleep.


        The connection between hydroxychloroquine and drowsiness is multifaceted and not yet fully understood. Although drowsiness is not typically cited as a direct side effect of the medication, individual reactions to drugs can vary significantly. Moreover, the potential influence on lysosomal function adds complexity to this issue. If you are experiencing that hydroxychloroquine make you sleepy then kindly communicate with your doctor.

        Leave a Comment

        Your email address will not be published. Required fields are marked *

        Scroll to Top