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If major dangerous signs are noted from overdosage or sensitivity, it has been suggested that ammonium chloride (8 g daily in separated doses for grownups) be provided orally 3 or 4 days a week for numerous months after therapy has actually been quit, as acidification of the urine enhances kidney excretion of the 4-aminoquinoline compounds by 20 % to 90 %. Surpassing the advised day-to-day dose sharply increases the risk of retinal poisoning.

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Reductions: 400 milligrams (310 mg base) orally on the exact same day weekly Suppressive therapy need to start 2 weeks before direct exposure; nevertheless, failing this, a preliminary dose of 800 mg (620 mg base) may be absorbed 2 separated doses (6 hours apart).